Pseudomonas aeruginosa is a gramnegative, aerobic rod bacterium of the pseudomonadaceae family a member of the gammaproteobacteria 142. Pseudomonas aeruginosa information and epidemiology services. Pseudomonas aeruginosa is the most common diseasecausing species. Pseudomonas aeruginosa is also of grave concern to cancer and burn patients as well as those people who are immunocompromised. Toxin a is toxic to animals and cultured cells, but the proenzyme has little or no enzymatic activity.
The case fatality rate for individuals infected with pseudomonas aeruginosa approaches 50 percent. Pseudomonas aeruginosa exotoxin a and keratitis in mice iovs. These compounds were first isolated from the cyanobacterium microcystis aeruginosa and therefore the toxins were named microcystins carmichael et al. Pseudomonas aeruginosa is an important bacterial pathogen, particularly as a cause of infections in hospitalised patients, immunocompromised hosts and patients with cystic fibrosis. Toxins free fulltext the role of pseudomonas aeruginosa exoy. Pseudomonas aeruginosa is a common bacterium, gramnegative opportunistic pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. Pseudomonas aeruginosa is the most common diseasecausing species, according to the centers for disease control and. Pdf pseudomonas aeruginosa pathogenesis and pathogenic. Classification of pseudomonas toxins and enzymes of pseudomonas resistance of pseudomonas pathogenicity of. In this article we will discuss about pseudomonas which is a human pathogen. Semantic scholar extracted view of extracellular toxins of pseudomonas aeruginosa. The effector protein exotoxin y exoy produced by pseudomonas aeruginosa is injected via the type iii secretion system t3ss into host cells.
Pseudomonas is a group of bacteria that can cause various types of infections. Table 272 shows the relationship between the various forms of toxin a and their enzymatic activity and mouse toxicity. Pseudomonas exotoxin a pe is the most toxic virulence factor of the pathogenic bacterium pseudomonas aeruginosa. Pseudomonas aeruginosa an overview sciencedirect topics. Exoenzyme s has the characteristic subunit structure of the acomponent of a bacterial toxin, and it has adpribosylating activity for a variety of eucaryotic proteins characteristic of many bacterial exotoxins. Also like diphtheria toxin, pseudomonas toxin a is released by p aeruginosa as a proenzyme. These two strains differ phenotypically in their expression of type iii secreted toxins. A type vi secretion system of pseudomonas aeruginosa targets a toxin to bacteria. Pseudomonas aeruginosa is primarily a nosocomial pathogen.1162 714 1315 608 192 1170 1157 228 521 520 1373 97 257 1457 603 478 1043 621 135 968 362 1215 296 819 884 942 654 433 1040 1320 895 307 173 739 778 235 740